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diazepam decreases levels of acetaminophen rectal by rising metabolism. Minimal/Significance Mysterious. Enhanced metabolism incr amounts of hepatotoxic metabolites.lapatinib will enhance the degree or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.levonorgestrel oral/ethinylestradiol/ferrous bisgly